2. Signaling Pathways
  3. PROTAC
  4. PROTAC Linkers

PROTAC Linkers

PROTAC Linkers

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PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.

The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.

PROTAC Linkers Isoform Specific Products:

PROTAC Linkers Isoform Comparison
Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-W018745
    Tetraethylene glycol 112-60-7 99.97%
    Tetraethylene glycol (PROTAC Linker 18) is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
    Tetraethylene glycol
  • HY-140915
    Biotin-PEG4-Picolyl azide 2222687-71-8 98.66%
    Biotin-PEG4-Picolyl azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Biotin-PEG4-Picolyl azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Biotin-PEG4-Picolyl azide
  • HY-140820
    Bromo-PEG3-azide 1446282-43-4
    Bromo-PEG4-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Bromo-PEG3-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Bromo-PEG3-azide
  • HY-133399
    Alkyne-PEG4-maleimide 1609651-90-2
    Alkyne-PEG4-maleimide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Alkyne-PEG4-maleimide is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Alkyne-PEG4-maleimide
  • HY-140696
    m-PEG-OH (MW 2000) 9004-74-4
    m-PEG-OH (MW 2000) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    m-PEG-OH (MW 2000)
  • HY-134720
    Amine-PEG4-Desthiobiotin 2306109-91-9 99.23%
    Amine-PEG4-Desthiobiotin is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Amine-PEG4-Desthiobiotin
  • HY-140468
    Boc-N-amido-PEG3-acid 1347750-75-7 99.62%
    Boc-N-amido-PEG3-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Boc-N-amido-PEG3-acid
  • HY-42145
    3-Maleimidopropionic acid 7423-55-4 99.83%
    3-Maleimidopropionic acid is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.
    3-Maleimidopropionic acid
  • HY-120537
    m-PEG5-CH2COOH 16142-03-3 99.90%
    m-PEG5-CH2COOH is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). m-PEG5-CH2COOH is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    m-PEG5-CH2COOH
  • HY-141213
    Bromo-PEG2-alcohol 57641-66-4 98.98%
    Bromo-PEG2-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Bromo-PEG2-alcohol
  • HY-140761
    Azido-PEG16-NHS ester 99.91%
    Azido-PEG16-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG16-NHS ester is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG16-NHS ester
  • HY-126891
    Bis-PEG3-acid 96517-92-9
    Bis-PEG3-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
    Bis-PEG3-acid
  • HY-141364
    Bromo-PEG1-C2-Boc 1393330-36-3 98.58%
    Bromo-PEG1-C2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Bromo-PEG1-C2-Boc
  • HY-W025812
    Boc-NH-PEG2-CH2CH2COOH 1365655-91-9 98.0%
    Boc-NH-PEG2-CH2CH2COOH is a PEG-based PROTAC linker can be used in the synthesis of PROTAC.
    Boc-NH-PEG2-CH2CH2COOH
  • HY-126886
    Mal-PEG1-NHS ester 1807518-72-4 99.63%
    Mal-PEG1-NHS ester is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Mal-PEG1-NHS ester is PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Mal-PEG1-NHS ester
  • HY-22335
    Amino-PEG4-C2-amine 68960-97-4 98.0%
    Amino-PEG4-C2-amine is a PEG-based (4 units) PROTAC linker can be used in the synthesis of PROTACs.
    Amino-PEG4-C2-amine
  • HY-140706
    m-PEG-thiol (MW 2000) 134874-49-0 98.0%
    m-PEG-thiol (MW 2000) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    m-PEG-thiol (MW 2000)
  • HY-W018464
    N-Boc-serinol 125414-41-7
    N-Boc-serinol is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs.
    N-Boc-serinol
  • HY-140456
    Azido-PEG12-acid 2152679-71-3 99.81%
    Azido-PEG12-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG12-acid is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG12-acid
  • HY-129622A
    NH2-PEG5-C6-Cl hydrochloride 2241669-16-7 98.0%
    NH2-PEG5-C6-Cl hydrochloride is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    NH2-PEG5-C6-Cl hydrochloride
PROTAC Linkers Isoform Comparison

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