2. Signaling Pathways
  3. PROTAC
  4. PROTAC Linkers

PROTAC Linkers

PROTAC Linkers

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PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.

The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.

PROTAC Linkers Isoform Specific Products:

PROTAC Linkers Isoform Comparison
Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-42773
    tert-Butyl (8-aminooctyl)carbamate 88829-82-7
    tert-Butyl (8-aminooctyl)carbamate (1-Boc-1,8-diaminooctane) can be used as a PROTAC linker in the synthesis of PROTACs. tert-butyl (8-aminooctyl)carbamate is an alkane chain with terminal amine and Boc-protected amino groups. Amine group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The Boc group can be deprotected under mild acidic conditions to form the free amine.
    tert-Butyl (8-aminooctyl)carbamate
  • HY-133399
    Alkyne-PEG4-maleimide 1609651-90-2
    Alkyne-PEG4-maleimide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Alkyne-PEG4-maleimide is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Alkyne-PEG4-maleimide
  • HY-133388
    Boc-NH-C12-NH2 109792-60-1 ≥98.0%
    Boc-NH-C12-NH2 is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs.
    Boc-NH-C12-NH2
  • HY-130659
    Amino-PEG8-amine 82209-36-7 ≥98.0%
    Amino-PEG8-amine is a PEG-based (8 units) PROTAC linker can be used in the synthesis of PROTACs.
    Amino-PEG8-amine
  • HY-W091879
    tert-Butyl 7-bromoheptanoate 51100-47-1
    tert-Butyl 7-bromoheptanoate is a PROTAC linker can be used in the synthesis of PROTACs, such as MCB-36 (HY-176786).
    tert-Butyl 7-bromoheptanoate
  • HY-141364
    Bromo-PEG1-C2-Boc 1393330-36-3 98.58%
    Bromo-PEG1-C2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Bromo-PEG1-C2-Boc
  • HY-W025812
    Boc-NH-PEG2-CH2CH2COOH 1365655-91-9 ≥98.0%
    Boc-NH-PEG2-CH2CH2COOH is a PEG-based PROTAC linker can be used in the synthesis of PROTAC.
    Boc-NH-PEG2-CH2CH2COOH
  • HY-22335
    Amino-PEG4-C2-amine 68960-97-4 ≥98.0%
    Amino-PEG4-C2-amine is a PEG-based (4 units) PROTAC linker can be used in the synthesis of PROTACs.
    Amino-PEG4-C2-amine
  • HY-W040231
    Fmoc-NH-PEG3-CH2CH2COOH 867062-95-1 99.79%
    Fmoc-NH-PEG3-CH2CH2COOH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Fmoc-NH-PEG3-CH2CH2COOH is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Fmoc-NH-PEG3-CH2CH2COOH
  • HY-W018464
    N-Boc-serinol 125414-41-7
    N-Boc-serinol is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs.
    N-Boc-serinol
  • HY-140820
    Bromo-PEG3-azide 1446282-43-4
    Bromo-PEG4-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Bromo-PEG3-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Bromo-PEG3-azide
  • HY-W012001
    N-Boc-7-aminoheptanoic acid 60142-89-4 ≥98.0%
    Boc-7-Aminoheptanoic acid can be used as a PROTAC linker in the synthesis of PROTACs and other conjugation applications. Boc-7-Aminoheptanoic acid is an alkane chain with terminal carboxlic acid and Boc-protected amino groups. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The Boc group can be deprotected under mild acidic conditions to form the free amine.
    N-Boc-7-aminoheptanoic acid
  • HY-W040134
    Mal-amido-PEG4-NHS ester 756525-99-2 99.24%
    Mal-amido-PEG4-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Mal-amido-PEG4-NHS ester
  • HY-W040236
    m-PEG8-Amine 869718-81-0 ≥98.0%
    m-PEG8-Amine is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
    m-PEG8-Amine
  • HY-W034595
    Eicosanedioic acid 2424-92-2 ≥99.0%
    Eicosanedioic acid is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Eicosanedioic acid is also a alkyl chain-based PROTAC linker that can be used in the synthesis
    Eicosanedioic acid
  • HY-140696
    m-PEG-OH (MW 2000) 9004-74-4
    m-PEG-OH (MW 2000) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    m-PEG-OH (MW 2000)
  • HY-W008568
    Fmoc-amino-PEG3-CH2COOH 139338-72-0 99.81%
    Fmoc-amino-PEG3-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Fmoc-amino-PEG3-CH2COOH
  • HY-W004896
    Boc-NH-PEG2 139115-91-6 99.78%
    Boc-NH-PEG2 (PROTAC Linker 11) is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
    Boc-NH-PEG2
  • HY-135796
    m-PEG3-OH 112-35-6 99.86%
    m-PEG3-alcohol is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
    m-PEG3-OH
  • HY-141230
    Hexaethylene glycol 2615-15-8 99.53%
    Hexaethylene glycol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Hexaethylene glycol
PROTAC Linkers Isoform Comparison

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